Best Nootropics to Help Boost Brain Function in 2021

Do you sometimes experience brain fog, memory issues or a lackluster mood? Researchers are working hard to figure out why this happens and what we can do to keep the brain functioning optimally in healthy adults.

Wellness experts are using this information to develop new ways of enhancing brain health with nootropics, sometimes called “smart drugs,” that support cognitive performance like memory, creativity, mental processing speed and even your mood.

We checked in with Herbalist and Nutritionist Cheryl Birky in Greenwood Village to learn more about how natural nootropics and nootropic stacks can help support cognitive function and enhance mental performance without the need for prescription drugs.

Amino acids and essential fatty acids make our brain work

Certain amino acids work as neurotransmitters or messengers that send chemical impulses between nerve cells in our brain. The faster and clearer these messages cross brain cells, the better we think and learn.

Essential fatty acids are nutrients that build healthy cell membranes and keep our brain’s nerve cells flexible over the long term, making the impulses easier to transfer from cell to cell, according to Cheryl.

Amino acids and essential fatty acids can be made by our bodies, converted from the foods we eat or come from concentrated supplements. The interplay of amino acids and fatty acids are critical to brain performance and affect a lot of functions including memory, mood, concentration, sleep and learning.

Here are some of the most important nootropics to know about.

Amino acids

  • ALCAR (acetyl-l-carnitine) forms acetylcholine, the primary neurotransmitter needed for memory and learning. ALCAR can improve overall cognition in the elderly and help support alertness. Because it’s naturally found in red meat and dairy products, vegans can benefit from supplementation.
  • Creatine (made from the amino acids glycine and arginine) increases energy in the brain and supports short-term memory and learning. Students and test-takers pay attention!
  • Taurine helps new brain cells grow and helps produce another neurotransmitter called GABA that helps calm our nervous system and lessen anxiety. It can help focus a distracted mind and help improve mental clarity.
  • L-Tryptophan is absorbed into the brain after eating foods rich in this amino acid; there it’s converted into serotonin (which affects positive moods) and melatonin (which helps us sleep).
  • Tyrosine (from amino acid phenylalanine) is converted to the neurotransmitter dopamine in the brain, which affects learning and motivation and reduces stress.
  • Theanine, an amino acid found in high concentrations in tea (especially black), affects our brain by reducing stress and improving cognition and focus. Studies show it helps children with ADHD sleep better too.

Essential fatty acids

Nootropic Stacks make it easy to get the benefits of brain-boosting nootropics

Here’s an example of a popular nootropic stack that Cheryl says has a unique formulation of brain-supporting amino acids and essential fatty acids.


Onnit Alpha Brain combines the amino acids tyrosine and theanine and essential fatty acid phosphatidylserine with botanical bacopa and oat straw, which are particularly helpful in addressing stress-induced memory issues, helping us recall information easier and focusing better, making it a favorite of college students.



Still not sure which “smart drug” is the right fit for your needs? Take a look at all the high quality nootropic supplements & nootropic stacks available online at Pharmaca so the right one finds its way into your cart.

Need more information about nootropic stacks? You can learn more about The Best Nootropic Stacks of 2021 and much more here at Project Wellness!