VSL#3 vs. Visbiome: What’s the Difference?

VSL#3 was a proprietary probiotic formula that was temporarily discontinued and became available as Visbiome High Potency Probiotic via a different pharmaceutical company. Now both products are back on the market. Here’s more about the difference.

What is the De Simone Formulation?
In the early 1990s, Professor Claudio De Simone invented a high-potency, 8-strain probiotic that could be used for dietary conditions. Known as the De Simone Formulation, the medical food contained a secret formulation of probiotic strains and a proprietary manufacturing process owned by Professor De Simone.

What is Visbiome?
Visbiome was created using the De Simone Formulation. It can be used for a variety of health conditions such as irritable bowel syndrome, ulcerative colitis and pouchitis. It qualifies as a non-drug therapy and maintains one of the highest concentrations of probiotic bacteria of any medical food on the market. Visbiome has been subject to more than 70 human clinical trials for dietary management of these conditions.

What is VSL#3?
VSL#3 is a non-dairy probiotic medical food that delivers a high concentration of beneficial bacteria (from 112.5 billion per capsule to 900 billion per packet). VSL#3 is a probiotic medical food for the dietary management of irritable bowel syndrome and ulcerative colitis, consisting of 8 strains of live freeze-dried lactic acid bacteria.

What is the difference between VSL#3 and Visbiome?
In the early 1990s, the De Simone Formulation and its associated patent was licensed by VSL Pharmaceuticals, Inc, to create the original VSL#3. In January of 2016, Professor De Simone terminated his relationship with VSL Pharmaceuticals and partnered with ExeGi Pharma to create the new brand using his original De Simone Formulation, now known as Visbiome. At that time VSL#3 was reformulated to its current iteration, and that formulation has not changed since 2016.

Today, both versions of this probiotic medical food—VSL#3 and Visbiome—are available to consumers.