VSL#3 vs. Visbiome: What’s the Difference?

VSL#3 was a proprietary probiotic formula that was recently discontinued. But the very same formulation is now available as Visbiome High Potency Probiotic. Here’s more about the transition.

What is the De Simone Formulation?
In the early 1990s, Professor Claudio De Simone invented a high-potency, 8-strain probiotic that could be used for dietary conditions. Known as the De Simone Formulation, the medical food contained a secret formulation of probiotic strains and a proprietary manufacturing process owned by Professor De Simone.

What is Visbiome?
Visbiome was created using the De Simone Formulation. It can be used for a variety of health conditions such as irritable bowel syndrome, ulcerative colitis and pouchitis. It qualifies as a non-drug therapy and maintains one of the highest concentrations of probiotic bacteria of any medical food on the market. Visbiome has been subject to more than 70 human clinical trials for dietary management of these conditions.

What is the difference between VSL#3 and Visbiome?
In short, the difference is in name only.

In the early 1990s, the De Simone Formulation and its associated patent was licensed by VSL Pharmaceuticals, Inc, to create the original VSL#3. In January of 2016, Professor De Simone terminated his relationship with VSL Pharmaceuticals and partnered with ExeGi Pharma to create the new brand using his original De Simone Formulation, now known as Visbiome.

After Professor De Simone and VSL Pharmaceuticals separated, VSL Pharmaceuticals attempted to create their own version of De Simone’s Formulation and continued to market it as VSL#3. In a recent US court ruling, it was determined that this new version of VSL#3 was not the same formula used in the original clinical trials and the copycat product was taken off the market.

Visbiome is now the only product that rightfully uses the De Simone Formulation.